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Article

Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs.

Development (Cambridge, England) - 1 Aug 2008

Menke Douglas B, Guenther Catherine, Kingsley David M

Abstract excerpt

The Tbx4 transcription factor is crucial for normal hindlimb and vascular development, yet little is known about how its highly conserved expression patterns are generated. We have used comparative genomics and functional scanning in transgenic mice to identify a dispersed group of enhancers controlling Tbx4 expression in different tissues. Two independent enhancers control hindlimb expression, one located...

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Share to Bone and Bones
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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18579682
DOI: 10.1242/dev.017384

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