Article
Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype.
Biochimie - 1 Jun 2020
Amenyah Sophia D, McMahon Amy, Ward Mary, Deane Jennifer, McNulty Helene, Hughes Catherine F, Strain J J, Horigan Geraldine, Purvis John, Walsh Colum P, Lees-Murdock Diane J
Abstract excerpt
DNA methylation is important in regulating gene expression and genomic stability while aberrant DNA methylation is associated with disease. Riboflavin (FAD) is a cofactor for methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate recycling, which generates methyl groups for homocysteine remethylation to methionine, the pre-cursor to the universal methyl donor S-adenosylmethionine (SAM). A...
Topics
- Aged
- DNA Methylation
- Female
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Observational Studies as Topic
- Randomized Controlled Trials as Topic