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Article

Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2013

Wilson Carol P, McNulty Helene, Ward Mary, Strain J J, Trouton Tom G, Hoeft Birgit A, Weber Peter, Roos Franz F, Horigan Geraldine, McAnena Liadhan, Scott John M

Abstract excerpt

Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Whether this effect is confined to patients with high-risk cardiovascular disease is unknown. The aim of this randomized trial,...

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Identifiers

PMID: 23608654
DOI: 10.1161/HYPERTENSIONAHA.111.01047

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.PMID 23608654Read ↗

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