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Article

Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.

Biochimie - 1 Jun 2020

Rooney Martina, Bottiglieri Teodoro, Wasek-Patterson Brandi, McMahon Amy, Hughes Catherine F, McCann Adrian, Horigan Geraldine, Strain J J, McNulty Helene, Ward Mary

Abstract excerpt

Homozygosity for the C677T polymorphism in MTHFR (TT genotype) is associated with a 24-87% increased risk of hypertension. Blood pressure (BP) lowering was previously reported in adults with the TT genotype, in response to supplementation with the MTHFR cofactor, riboflavin. Whether the BP phenotype associated with the polymorphism is related to perturbed one-carbon metabolism is unknown. This study investigated...

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Identifiers

PMID: 32330571
DOI: 10.1016/j.biochi.2020.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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