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Article

Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).

The Journal of biological chemistry - 19 Mar 2010

Sun Wei, Jin Junfei, Xu Ruijuan, Hu Wei, Szulc Zdzislaw M, Bielawski Jacek, Obeid Lina M, Mao Cungui

Abstract excerpt

Human alkaline ceramidase 2 (ACER2) plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells. Here we report its biochemical characterization, membrane topology, and activity regulation. Recombinant ACER2 was expressed in yeast mutant cells (Deltaypc1Deltay...

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Identifiers

PMID: 20089856
DOI: 10.1074/jbc.M109.069203
PMCID: PMC2838321

Genes

ACER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20089856-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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