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Article

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice.

Journal of lipid research - 1 Apr 2011

Zhang Yao, Cheng Yajun, Hansen Gert H, Niels-Christiansen Lise-Lotte, Koentgen Frank, Ohlsson Lena, Nilsson Ake, Duan Rui-Dong

Abstract excerpt

Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and studied SM digestion. Both wild-type (WT) an...

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Identifiers

PMID: 21177474
DOI: 10.1194/jlr.M012880
PMCID: PMC3284167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21177474-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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