Article

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

2026-05-04

Abstract excerpt

The pace of ageing varies markedly among vertebrate species and individuals. However, the mechanisms underlying these differences in ageing rates remain unclear. Here, we show that the activity of the gut ceramidase Asah2 determines species- and strain-specific rates of vertebrate ageing. Comparative genomic analyses of vertebrate species and strains with different ageing rates reveal an association between low As...

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Literature Corpus work: ee89e12e-4a48-5cdd-b864-9d94f06c9a80
DOI: 10.64898/2026.04.30.721799

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