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Article

Sphingosine kinase SPHK-1 maintains sphingolipid metabolism to protect lysosome membrane integrity in C. elegans.

Molecular biology of the cell - 1 Jan 2026

Li Yuan, Zhang Jie, Li Meijiao, Yang Lujia, Wang Xiaochen

Abstract excerpt

The maintenance of lysosome membrane integrity is vital for cell homeostasis and viability, but the underlying mechanisms are not well understood. In this study, we identified a novel role of SPHK-1, the sole Caenorhabditis elegans sphingosine kinase, in protecting lysosome membrane integrity. Loss of SPHK-1 affects lysosomal integrity and degradative function, causing cargo accumulation and lysosome membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41191545
DOI: 10.1091/mbc.E25-04-0182
PMCID: PMC12696880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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