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Article

Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.

Immunological reviews - 1 Apr 1998

Stevenson F, Sahota S, Zhu D, Ottensmeier C, Chapman C, Oscier D, Hamblin T

Abstract excerpt

Recombination of VH, DH and JH genes is a unique first step in normal B-cell development. Subsequent differentiation to a mature plasma cell is accompanied by further events in the Ig genes, including VL-JL joining, somatic hypermutation and isotype switching. Chromosomal changes leading to B-cell tumors can occur at many points in this sequence, and may be partly a consequence of the genetic mobility and...

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Share to Amino Acid Sequence
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9602369
DOI: 10.1111/j.1600-065x.1998.tb01446.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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