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Article

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment

18 Dec 2017

Abstract excerpt

Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. P-glycoprotein (P-gp), a promiscuous drug efflux pump, has been extensively studied for its association with MDR due to overexpression in cancer cells. Several P-gp inhibitors or modulators have been investigated in clinical trials in hope of circumventing MDR, with only limited success. Alternative strategies are actively pursued,...

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PMID: 29251920
DOI: 10.1021/acs.jmedchem.7b01457

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