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Article

Multidrug Resistance in Cancer: Its Mechanism and its Modulation

1 Jan 2007

Abstract excerpt

One of the major problems related with the curative treatment of cancer patients is resistance against anticancer drugs. This resistance, which may occur from the beginning or is evident only later as an acquired phenomenon, is due to the action of drug transporters. These transmembrane proteins belong to the ATP-binding cassette (ABC) transporters which reduce bioavailability of drugs, but also determine the...

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PMID: 17925891
DOI: 10.1358/dnp.2007.20.6.1141496

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