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Article

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.

Seminars in cell & developmental biology - 1 Jun 2001

Hrycyna C A

Abstract excerpt

A variety of human cancers become resistant or are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due in large part to the overexpression of a 170 kDa plasma membrane ATP-dependent pump known as the multidrug resistance transporter or P-glycoprotein. P-glycoprotein is a member of the large ATP binding cassette (ABC) superfamily of membrane transporters. This review...

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PMID: 11428917
DOI: 10.1006/scdb.2000.0250

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