Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomics and the mechanism of P-glycoprotein (ABCB1).

Journal of bioenergetics and biomembranes - 1 Dec 2007

Sauna Zuben E, Kim In-Wha, Ambudkar Suresh V

Abstract excerpt

The development of effective clinical interventions against multidrug resistance (MDR) in cancer remains a significant challenge. Single nucleotide polymorphisms (SNPs) contribute to wide variations in how individuals respond to medications and there are several SNPs in human P-glycoprotein (P-gp) that may influence the interactions of drug-substrates with the transporter. Interestingly, even some of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Biological Transport

Share to Drug Resistance, Multiple

Share to Genes, MDR

Share to Genome, Human

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 18058211
DOI: 10.1007/s10863-007-9115-9

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomics and the mechanism of P-glycoprotein (ABCB1).PMID 18058211Read ↗

Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.Semantic proximity Read ↗

The Structure and Functions of P-GlycoproteinSemantic proximity Read ↗

The translocation mechanism of P‐glycoproteinSemantic proximity Read ↗

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Semantic proximity Read ↗

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.Semantic proximity Read ↗

The ABCG2/BCRP transporter and its variants - from structure to pathology.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

[ABC transporters' impact on effect and metabolism of drugs].Semantic proximity Read ↗

[MDR1 (ABCB1) gene encoding glycoprotein P (P-gp), a member of ABC transporter superfamily: consequences for therapy and progression of neoplastic diseases].Semantic proximity Read ↗

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition.Semantic proximity Read ↗

An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.Semantic proximity Read ↗

ATP binding cassette systems: structures, mechanisms, and functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.