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Article

The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data.

Neurobiology of aging - 1 Jan 2007

Bertram Lars, Hsiao Monica, McQueen Matthew B, Parkinson Michele, Mullin Kristina, Blacker Deborah, Tanzi Rudolph E

Abstract excerpt

Genetic linkage studies suggest the presence of an Alzheimer's disease (AD) risk gene on chromosome 19, acting independently of apolipoprotein E (apoE), a known AD risk factor on 19q13. The low density lipoprotein receptor (LDLR) is an interesting candidate because it maps within the linked interval, and is intimately involved in cholesterol homeostasis and the function of apoE. We tested three previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16378661
DOI: 10.1016/j.neurobiolaging.2005.11.005

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data.PMID 16378661Read ↗

Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease.Semantic proximity Read ↗

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Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs.Semantic proximity Read ↗

Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease.Semantic proximity Read ↗

No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.Semantic proximity Read ↗

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