Article
No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.
Neurogenetics - 1 Mar 1998
Scott W K, Yamaoka L H, Bass M P, Gaskell P C, Conneally P M, Small G W, Farrer L A, Auerbach S A, Saunders A M, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
The low-density lipoprotein receptor-related protein gene (LRP1) is often mentioned as a candidate gene for Alzheimer disease (AD) because of its role as a receptor for apolipoprotein E (apoE), a major genetic risk factor for late-onset familial and sporadic AD. A recent association study of a tetranucleotide repeat polymorphism located 5' to the LRP1 gene detected an increase in the 87 base pair allele in AD...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- DNA
- Family Health
- Female
- Gene Frequency
- Genotype
- Humans
- Lod Score
- Low Density Lipoprotein Receptor-Related Protein-1