Article
Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
Neurochemical research - 1 Jan 2000
Brown Abraham M, Gordon Derek, Lee Hsinhwa, Wavrant-De Vrièze Fabienne, Cellini Elena, Bagnoli Silvia, Nacmias Benedetta, Sorbi Sandro, Hardy John, Blass John P
Abstract excerpt
Prior case-control studies from our laboratory of a population enriched with individuals of Ashkenazi Jewish descent suggested that association exists between Alzheimer's disease (AD) and the chromosomal region near the DLD gene, which encodes the mitochondrial dihydrolipoamide dehydrogenase enzyme. In support of this finding, we found that linkage analysis restricted to autopsy-proven patients in the National...
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