Article
Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.
Genes & development - 15 Dec 2000
Barbosa V, Yamamoto R R, Henderson D S, Glover D M
Abstract excerpt
We have cloned the Drosophila gene discs degenerate-4 (dd4) and find that it encodes a component of the gamma-tubulin ring complex (gammaTuRC) homologous to Spc98 of budding yeast. This provides the first opportunity to study decreased function of a member of the gamma-tubulin ring complex, other than gamma-tubulin itself, in a metazoan cell. gamma-tubulin is no longer at the centrosomes but is dispersed...
Topics
- Animals
- Centrosome
- Chromosomes
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Female
- Homeodomain Proteins
- Male
- Metaphase
- Microtubule Proteins
- Microtubule-Associated Proteins
- Microtubules
- Mitosis
- Mutation