Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.

Genes & development - 15 Dec 2000

Barbosa V, Yamamoto R R, Henderson D S, Glover D M

Abstract excerpt

We have cloned the Drosophila gene discs degenerate-4 (dd4) and find that it encodes a component of the gamma-tubulin ring complex (gammaTuRC) homologous to Spc98 of budding yeast. This provides the first opportunity to study decreased function of a member of the gamma-tubulin ring complex, other than gamma-tubulin itself, in a metazoan cell. gamma-tubulin is no longer at the centrosomes but is dispersed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centrosome
Share to Metaphase
Share to Microtubule-Associated Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microtubule Proteins

Share to Microtubules

Share to Mitosis

Share to Spindle Apparatus

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 11124805
DOI: 10.1101/gad.182800
PMCID: PMC317135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.PMID 11124805Read ↗

The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis.Semantic proximity Read ↗

The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.Semantic proximity Read ↗

GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.Semantic proximity Read ↗

Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function.Semantic proximity Read ↗

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.Semantic proximity Read ↗

Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.Semantic proximity Read ↗

The role of γ-tubulin in centrosomal microtubule organization.Semantic proximity Read ↗

The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers.Semantic proximity Read ↗

Flies without centrioles.Semantic proximity Read ↗

Drosophila dd4 mutants reveal that gammaTuRC is required to maintain juxtaposed half spindles in spermatocytes.Semantic proximity Read ↗

The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila.Semantic proximity Read ↗

The gammaTuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.