Article
A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.
PloS one - 10 Mar 2010
Manning Jantina A, Shalini Sonia, Risk Joanna M, Day Catherine L, Kumar Sharad
Abstract excerpt
The centrosome is the primary microtubule organizing centre of the cell. gamma-tubulin is a core component of the centrosome and is required for microtubule nucleation and centrosome function. The recruitment of gamma-tubulin to centrosomes is mediated by its interaction with NEDD1, a WD40-repeat containing protein. Here we demonstrate that NEDD1 is likely to be oligomeric in vivo and binds directly to...
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