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A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes.

Genes & development - 15 Aug 2009

Wainman Alan, Buster Daniel W, Duncan Tommy, Metz Jeremy, Ma Ao, Sharp David, Wakefield James G

Abstract excerpt

The Drosophila Augmin complex localizes gamma-tubulin to the microtubules of the mitotic spindle, regulating the density of spindle microtubules in tissue culture cells. Here, we identify the microtubule-associated protein Msd1 as a new component of the Augmin complex and demonstrate directly that it is required for nucleation of microtubules from within the mitotic spindle. Although Msd1 is necessary for...

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Identifiers

PMID: 19684111
DOI: 10.1101/gad.532209
PMCID: PMC2725934

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