Article
Small molecules that delay S phase suppress a zebrafish bmyb mutant.
Nature chemical biology - 1 Dec 2005
Stern Howard M, Murphey Ryan D, Shepard Jennifer L, Amatruda James F, Straub Christian T, Pfaff Kathleen L, Weber Gerhard, Tallarico John A, King Randall W, Zon Leonard I
Abstract excerpt
Bmyb is a ubiquitously expressed transcription factor involved in cellular proliferation and cancer. Loss of bmyb function in the zebrafish mutant crash&burn (crb) results in decreased cyclin B1 expression, mitotic arrest and genome instability. These phenotypic observations in crb mutants could be attributed to the decreased expression of cyclin B1, a cell-cycle regulatory protein that is responsible for driving...
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