Article
Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.
PloS one - 1 Jan 2009
Xiang Jing, Yang Hongbo, Che Chao, Zou Haixia, Yang Hanshuo, Wei Yuquan, Quan Junmin, Zhang Hui, Yang Zhen, Lin Shuo
Abstract excerpt
Cyclin-dependent kinases (CDKs) play important roles in regulating cell cycle progression, and altered cell cycles resulting from over-expression or abnormal activation of CDKs observed in many human cancers. As a result, CDKs have become extensive studied targets for developing chemical inhibitors for cancer therapies; however, protein kinases share a highly conserved ATP binding pocket at which most chemical...
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