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Zebrafish screen identifies novel compound with selective toxicity against leukemia

9 Apr 2012

Abstract excerpt

To detect targeted antileukemia agents we have designed a novel, high-content in vivo screen using genetically engineered, T-cell reporting zebrafish. We exploited the developmental similarities between normal and malignant T lymphoblasts to screen a small molecule library for activity against immature T cells with a simple visual readout in zebrafish larvae. After screening 26 400 molecules, we identified...

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PMID: 22490804
DOI: 10.1182/blood-2011-12-398818

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