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Article

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.

PLoS biology - 1 Dec 2004

Eggert Ulrike S, Kiger Amy A, Richter Constance, Perlman Zachary E, Perrimon Norbert, Mitchison Timothy J, Field Christine M

Abstract excerpt

Cytokinesis involves temporally and spatially coordinated action of the cell cycle and cytoskeletal and membrane systems to achieve separation of daughter cells. To dissect cytokinesis mechanisms it would be useful to have a complete catalog of the proteins involved, and small molecule tools for specifically inhibiting them with tight temporal control. Finding active small molecules by cell-based screening...

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Identifiers

PMID: 15547975
DOI: 10.1371/journal.pbio.0020379
PMCID: PMC528723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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