Article
A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis
2021-03-05
Abstract excerpt
Metastasis is responsible for approximately 90% of cancer-associated mortality but few models exist that allow for rapid and effective screening of anti-metastasis drugs. Current mouse models of metastasis are too expensive and time consuming to use for rapid and high-throughput screening. Therefore, we created a unique screening concept utilizing conserved mechanisms between zebrafish gastrulation and cancer meta...
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Identifiers and source
- Literature Corpus work
- 94c1e458-9a6c-5fc8-9354-1b3b45e7806a
- DOI
- 10.1101/2021.03.04.434001