Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2006

Qin Zhenyu, Itoh Shinichi, Jeney Viktoria, Ushio-Fukai Masuko, Fukai Tohru

Abstract excerpt

Extracellular superoxide dismutase (SOD3), a secretory copper enzyme, plays an important role in atherosclerosis and hypertension by modulating the levels of extracellular superoxide anion (O2*-) in the vasculature. Little is known about the mechanisms by which SOD3 obtains its catalytic copper cofactor. Menkes ATPase (MNK) has been shown to transport cytosolic copper to the secretory pathway in nonvascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Copper

Share to Copper-Transporting ATPases

Share to Endothelial Cells

Share to Muscle, Smooth, Vascular

Share to Superoxide Dismutase

Share to trans-Golgi Network

Source

Identifiers

PMID: 16371425
DOI: 10.1096/fj.05-4564fje

Genes

SOD3
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.PMID 16371425Read ↗

Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function.Semantic proximity Read ↗

SOD3 Variant, R213G, Altered SOD3 Function, Leading to ROS-Mediated Inflammation and Damage in Multiple Organs of Premature Aging Mice.Semantic proximity Read ↗

The Menkes copper transporter is required for the activation of tyrosinase.Semantic proximity Read ↗

Distinct Functional Roles for the Menkes and Wilson Copper Translocating P-type ATPases in Human Placental CellsSemantic proximity Read ↗

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cellsSemantic proximity Read ↗

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase.Semantic proximity Read ↗

Genetic silencing of K <sub>Ca</sub> 3.1 inhibits atherosclerosis in ApoE null miceSemantic proximity Read ↗

A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution.Semantic proximity Read ↗

Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase.Semantic proximity Read ↗

[Physiological significance of superoxide dismutase isozymes].Semantic proximity Read ↗

Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase.Semantic proximity Read ↗

Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.