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Article

Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase.

The Journal of biological chemistry - 29 Aug 2003

Bartnikas Thomas B, Gitlin Jonathan D

Abstract excerpt

Copper/zinc superoxide dismutase (SOD1) is an abundant intracellular enzyme with an essential role in antioxidant defense. The activity of SOD1 is dependent upon the presence of a bound copper ion incorporated by the copper chaperone for superoxide dismutase, CCS. To elucidate the cell biological mechanisms of this process, SOD1 synthesis and turnover were examined following 64Cu metabolic labeling of fibroblasts...

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Source

Identifiers

PMID: 12815046
DOI: 10.1074/jbc.M305435200

Genes

SOD1
CCS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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