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Article

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Wong P C, Waggoner D, Subramaniam J R, Tessarollo L, Bartnikas T B, Culotta V C, Price D L, Rothstein J, Gitlin J D

Abstract excerpt

Recent studies in Saccharomyces cerevisiae suggest that the delivery of copper to Cu/Zn superoxide dismutase (SOD1) is mediated by a cytosolic protein termed the copper chaperone for superoxide dismutase (CCS). To determine the role of CCS in mammalian copper homeostasis, we generated mice with targeted disruption of CCS alleles (CCS(-/-) mice). Although CCS(-/-) mice are viable and possess normal levels of SOD1...

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Identifiers

PMID: 10694572
DOI: 10.1073/pnas.040461197
PMCID: PMC16025

Genes

CCS
SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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