Article
The Menkes copper transporter is required for the activation of tyrosinase.
Human molecular genetics - 22 Nov 2000
Petris M J, Strausak D, Mercer J F
Abstract excerpt
Menkes disease is an X-linked recessive copper deficiency disorder caused by mutations in the ATP7A (MNK) gene. The MNK gene encodes a copper-transporting P-type ATPase, MNK, which is localized predominantly in the trans-Golgi network (TGN). The MNK protein relocates to the plasma membrane in cells exposed to elevated copper where it functions in copper efflux. A role for MNK at the TGN in mammalian cells has not...
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