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Article

Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2008

Qin Zhenyu, Gongora Maria Carolina, Ozumi Kiyoshi, Itoh Shinichi, Akram Kamran, Ushio-Fukai Masuko, Harrison David G, Fukai Tohru

Abstract excerpt

The extracellular superoxide dismutase (SOD3), a secretory copper-containing enzyme, regulates angiotensin II (Ang II)-induced hypertension by modulating levels of extracellular superoxide anion. The present study was designed to determine the role of the copper transporter Menkes ATPase (MNK) in Ang II-induced SOD3 activity and hypertension in vivo. Here we show that chronic Ang II infusion enhanced systolic...

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Identifiers

PMID: 18768397
DOI: 10.1161/HYPERTENSIONAHA.108.116467
PMCID: PMC2678052

Genes

SOD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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