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Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

12 Feb 2007

Abstract excerpt

Copper deficiency during pregnancy results in early embryonic death and foetal structural abnormalities including skeletal, pulmonary and cardiovascular defects. During pregnancy, copper is transported from the maternal circulation to the foetus by mechanisms which have not been clearly elucidated. Two copper-transporting ATPases, Menkes (ATP7A; MNK) and Wilson (ATP7B; WND), are expressed in the placenta and both...

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PMID: 17109627
DOI: 10.1042/bj20061099

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Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cellsPMID 17109627Read ↗

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Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase.Semantic proximity Read ↗

Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.Semantic proximity Read ↗

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.Semantic proximity Read ↗

Copper specifically regulates intracellular phosphorylation of the Wilson's disease protein, a human copper-transporting ATPase.Semantic proximity Read ↗

Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transportersSemantic proximity Read ↗

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