Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging.

doi:10.1161/01.HYP.0000247302.20559.3a

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Article

Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2006

Didion Sean P, Kinzenbaw Dale A, Schrader Laura I, Faraci Frank M

Abstract excerpt

The goal of this study was to test the hypothesis that loss of a single copy of the gene for CuZn superoxide dismutase (CuZnSOD) increases vascular superoxide levels and produces vascular dysfunction with aging. Responses of carotid arteries from young (7 months) and old (22 to 24 months of age) heterozygous CuZnSOD-deficient (CuZnSOD(+/-)) mice and their wild-type (CuZnSOD(+/+)) littermates were examined in...

Topics

Aging
Animals
Aortic Diseases
Carotid Artery Diseases
Female
Male
Mice
Oxidative Stress
Phenotype
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases
Superoxide Dismutase
Superoxides
Tunica Intima

Source

Open in PubMed

Identifiers

PMID: 17043164
DOI: 10.1161/01.HYP.0000247302.20559.3a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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