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Article

Structural polymorphism of the HIV-1 leader region explored by computational methods.

Nucleic acids research - 1 Jan 2005

Kasprzak Wojciech, Bindewald Eckart, Shapiro Bruce A

Abstract excerpt

Experimental studies revealed that the elements of the human immunodeficiency virus type 1 (HIV-1) 5'-untranslated leader region (5'-UTR) can fold in vitro into two alternative conformations, branched (BMH) and 'linearized' (LDI) and switch between them to achieve different functionality. In this study we computationally explored in detail, with our massively parallel genetic algorithm (MPGAfold), the propensity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16371347
DOI: 10.1093/nar/gki1015
PMCID: PMC1322270

Genes

MAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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