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Article

Determination of RNA structural diversity and its role in HIV-1 RNA splicing.

Nature - 1 Jun 2020

Tomezsko Phillip J, Corbin Vincent D A, Gupta Paromita, Swaminathan Harish, Glasgow Margalit, Persad Sitara, Edwards Matthew D, Mcintosh Lachlan, Papenfuss Anthony T, Emery Ann, Swanstrom Ronald, Zang Trinity, Lan Tammy C T, Bieniasz Paul, Kuritzkes Daniel R, Tsibris Athe, Rouskin Silvi

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-stranded RNA genome. HIV-1 must express all of its gene products from a single primary transcript, which undergoes alternative splicing to produce diverse protein products that include structural proteins and regulatory factors1,2. Despite the critical role of alternative splicing, the mechanisms that drive the choice of splice site...

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Share to Alternative Splicing
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32555469
DOI: 10.1038/s41586-020-2253-5
PMCID: PMC7310298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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