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Article

Role of Mutations in Differential Recognition of Viral RNA Molecules by Peptides.

Journal of chemical information and modeling - 25 Jul 2022

Kumar Amit, Vashisth Harish

Abstract excerpt

The conserved noncoding RNA elements in viral genomes interact with proteins to regulate various events during viral replication. We report studies on the recognition mechanisms of two helical peptides, namely, a native (Rev) peptide and a lab-evolved (RSG1.2) peptide, by a highly conserved viral RNA element from the human immunodeficiency virus 1 genome. Specifically, we investigated the physical interactions...

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Identifiers

PMID: 35833626
DOI: 10.1021/acs.jcim.2c00376
PMCID: PMC10129845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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