Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteins.

Genetics - 1 Apr 2002

Gómez Eliana B, Catlett Michael G, Forsburg Susan L

Abstract excerpt

The six conserved MCM proteins are essential for normal DNA replication. They share a central core of homology that contains sequences related to DNA-dependent and AAA(+) ATPases. It has been suggested that the MCMs form a replicative helicase because a hexameric subcomplex formed by MCM4, -6, and -7 proteins has in vitro DNA helicase activity. To test whether ATPase and helicase activities are required for MCM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalytic Domain

Share to Cell Cycle Proteins

Share to Cyclin-Dependent Kinases

Share to DNA Helicases

Share to Macromolecular Substances

Share to Schizosaccharomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 11973289
DOI: 10.1093/genetics/160.4.1305
PMCID: PMC1462049

Genes

MCM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteins.PMID 11973289Read ↗

ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.Semantic proximity Read ↗

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Semantic proximity Read ↗

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.Semantic proximity Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.Semantic proximity Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Semantic proximity Read ↗

Biochemical activities associated with mouse Mcm2 protein.Semantic proximity Read ↗

[MCM protein complex in fission yeast].Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.