Article
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.
Molecular and cellular biology - 1 Aug 2007
Tateno Hiroaki, Li Hongyi, Schur Melissa J, Bovin Nicolai, Crocker Paul R, Wakarchuk Warren W, Paulson James C
Abstract excerpt
Sialic acid-binding immunoglobulin-like lectins (siglecs) are predominately expressed on immune cells. They are best known as regulators of cell signaling mediated by cytoplasmic tyrosine motifs and are increasingly recognized as receptors for pathogens that bear sialic acid-containing glycans. Most siglec proteins undergo endocytosis, an activity tied to their roles in cell signaling and innate immunity. Here,...
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