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Article

Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: an alternative to in situ apoptosis.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

Stout Gerdine J, Westdijk Daniel, Calkhoven Dennis M, Pijper Olaf, Backendorf Claude M P, Willemze Rein, Mullenders Leon H F, de Gruijl Frank R

Abstract excerpt

The interplay among nucleotide excision repair, cell-cycle regulation, and apoptosis in the UV-exposed epidermis is extremely important to avoid mutations and malignant transformation. In Xpc(-/-) mice deficient in global genome nucleotide excision repair (GGR), a cell-cycle arrest of epidermal cells in late S-phase [with near-double normal diploid (4N) DNA content] was observed 48-72 h after UV exposure. This...

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Identifiers

PMID: 16365302
DOI: 10.1073/pnas.0505505102
PMCID: PMC1323157

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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