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The DNA damage response links human squamous proliferation with differentiation

1 Oct 2020

Abstract excerpt

How rapid cell multiplication leads to cell differentiation in developing tissues is still enigmatic. This question is central to morphogenesis, cell number control, and homeostasis. Self-renewal epidermoid epithelia are continuously exposed to mutagens and are the most common target of cancer. Unknown mechanisms commit rapidly proliferating cells to post-mitotic terminal differentiation. We have over-activated...

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PMID: 33007086
DOI: 10.1083/jcb.202001063

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