Article
Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.
Cancer research - 1 Jun 2000
Berg R J, Rebel H, van der Horst G T, van Kranen H J, Mullenders L H, van Vloten W A, de Gruijl F R
Abstract excerpt
The nucleotide excision repair (NER) system is comprised of two subpathways, i.e., transcription-coupled repair (TCR) and global genome repair (GGR). To establish the relative importance of TCR and GGR for UV effects on the skin, we have used hairless knockout mouse strain lacking either TCR (CSB -/-) or GGR (XPC -/-). In single exposure experiments, we found that CSB -/- mice have a 7-16 times higher...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.