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Article

Differential role of transcription-coupled repair in UVB-induced G 2 arrest and apoptosis in mouse epidermis

26 Sept 2000

Abstract excerpt

Nucleotide excision repair (NER), apoptosis, and cell-cycle regulation are major defense mechanisms against the carcinogenic effects of UVB light. NER eliminates UVB-induced DNA photolesions via two subpathways: global genome repair (GGR) and transcription-coupled repair (TCR). Defects in NER result in the human disorders xeroderma pigmentosum (XP) and Cockayne syndrome (CS), displaying severe UV sensitivity and...

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PMID: 11005836
DOI: 10.1073/pnas.200226697

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