Article
Nucleotide excision repair- and p53-deficient mouse models in cancer research.
Mutation research - 1 Jul 2005
Hoogervorst Esther M, van Steeg Harry, de Vries Annemieke
Abstract excerpt
Cancer is caused by the loss of controlled cell growth due to mutational (in)activation of critical genes known to be involved in cell cycle regulation. Three main mechanisms are known to be involved in the prevention of cells from becoming cancerous; DNA repair and cell cycle control, important to remove DNA damage before it will be fixed into mutations and apoptosis, resulting in the elimination of cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.