Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint

doi:10.1038/s41419-018-1130-8

Article

Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint

25 Oct 2018

Abstract excerpt

The epidermis is a self-renewal epithelium continuously exposed to the genotoxic effects of ultraviolet (UV) light, the main cause of skin cancer. Therefore, it needs robust self-protective mechanisms facing genomic damage. p53 has been shown to mediate apoptosis in sunburn cells of the epidermis. However, epidermal cells daily receive sublethal mutagenic doses of UV and massive apoptosis would be deleterious. We...

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