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Article

Selective DNA damage responses in murine Xpa-/-, Xpc-/- and Csb-/- keratinocyte cultures.

DNA repair - 21 Nov 2005

Stout Gerdine J, Oosten Marijke van, Acherrat Fatima Z, Wit Jan de, Vermeij Wilbert P, Mullenders Leon H F, Gruijl Frank R de, Backendorf Claude

Abstract excerpt

Cellular DNA damage responses (DDRs) are induced by unrepaired DNA lesions and constitute a protective back-up system that prevents the expansion of damaged cells. These cellular signaling pathways trigger either growth arrest or cell death and are believed to be major components of an early anti-cancer barrier. Cultures of C57BL/6J keratinocytes with various defects in NER sub-pathways allowed us to follow the...

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Identifiers

PMID: 16182614
DOI: 10.1016/j.dnarep.2005.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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