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Article

Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia.

Psychiatry research - 30 Jan 2006

Hirvonen Jussi, van Erp Theo G M, Huttunen Jukka, Någren Kjell, Huttunen Matti, Aalto Sargo, Lönnqvist Jouko, Kaprio Jaakko, Cannon Tyrone D, Hietala Jarmo

Abstract excerpt

The dopamine hypothesis of schizophrenia postulates that a dysfunctional dopaminergic system is a major pathophysiological mechanism in the disease. Most studies have focused on striatal dopamine D2 receptors, but a disturbed link between dopamine D1 and D2 receptors has also been proposed. Schizophrenia is highly heritable, and recent evidence suggests that alterations in the dopaminergic system confer...

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PMID: 16361088
DOI: 10.1016/j.pscychresns.2005.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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