Article
Tourette syndrome: prediction of phenotypic variation in monozygotic twins by caudate nucleus D2 receptor binding.
Science (New York, N.Y.) - 30 Aug 1996
Wolf S S, Jones D W, Knable M B, Gorey J G, Lee K S, Hyde T M, Coppola R, Weinberger D R
Abstract excerpt
Tourette syndrome, a chronic tic disorder with autosomal dominant inheritance, exhibits considerable phenotypic variability even within monozygotic twin pairs. The origins of this variability remain unclear. Recent findings have implicated the caudate nucleus as a locus of pathology, and pharmacological evidence supports dopaminergic involvement. Within monozygotic twins discordant for Tourette syndrome severity,...
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