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Article

Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.

Nature cell biology - 1 Aug 2009

Phillips Carolyn M, Meng Xiangdong, Zhang Lei, Chretien Jacqueline H, Urnov Fyodor D, Dernburg Abby F

Abstract excerpt

Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriched in the corresponding chromosome regions selectively recruit these proteins in vivo. In vitro...

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Identifiers

PMID: 19620970
DOI: 10.1038/ncb1904
PMCID: PMC4001799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.PMID 19620970Read ↗

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