Article
Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.
Nature cell biology - 1 Aug 2009
Phillips Carolyn M, Meng Xiangdong, Zhang Lei, Chretien Jacqueline H, Urnov Fyodor D, Dernburg Abby F
Abstract excerpt
Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short seq...
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