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Article

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster.

Nature genetics - 1 Oct 2005

Caussinus Emmanuel, Gonzalez Cayetano

Abstract excerpt

Loss of cell polarity and cancer are tightly correlated, but proof for a causative relationship has remained elusive. In stem cells, loss of polarity and impairment of asymmetric cell division could alter cell fates and thereby render daughter cells unable to respond to the mechanisms that control proliferation. To test this hypothesis, we generated Drosophila melanogaster larval neuroblasts containing mutations...

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PMID: 16142234
DOI: 10.1038/ng1632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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