Article
A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.
Genes & development - 1 Dec 1998
Cox D N, Chao A, Baker J, Chang L, Qiao D, Lin H
Abstract excerpt
Germ-line stem cells (GSCs) serve as the source for gametogenesis in diverse organisms. We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter GSC but is not essential for the further differentiati...
Topics
- Amino Acid Sequence
- Animals
- Arabidopsis
- Argonaute Proteins
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Division
- Cloning, Molecular
- Conserved Sequence
- Drosophila
- Drosophila Proteins
- Evolution, Molecular
- Female
- Genes, Insect
- Germ Cells