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Article

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal.

Genes & development - 1 Dec 1998

Cox D N, Chao A, Baker J, Chang L, Qiao D, Lin H

Abstract excerpt

Germ-line stem cells (GSCs) serve as the source for gametogenesis in diverse organisms. We cloned and characterized the Drosophila piwi gene and showed that it is required for the asymmetric division of GSCs to produce and maintain a daughter GSC but is not essential for the further differentiation of the committed daughter cell. Genetic mosaic and RNA in situ analyses suggest that piwi expression in adjacent...

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Identifiers

PMID: 9851978
DOI: 10.1101/gad.12.23.3715
PMCID: PMC317255

Genes

GSC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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