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Article

Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.

Oncology - 1 Jan 2009

Miyaki Michiko, Yamaguchi Tatsuro, Iijima Takeru, Takahashi Keiichi, Matsumoto Hiroshi, Mori Takeo

Abstract excerpt

OBJECTIVES: Cdc4 (Fbxw7) is a potential tumor suppressor that regulates ubiquitination and proteolysis of multiple targets such as cyclin E, c-Myc, c-Jun and Notch. CDC4 mutations were investigated in 194 colorectal carcinomas and adenomas for comparison between sporadic and hereditary cancers. METHODS: Mutations of the CDC4 gene were analyzed by PCR-SSCP and sequencing, and loss of heterozygosity (LOH) was...

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Source

Identifiers

PMID: 19420964
DOI: 10.1159/000217811

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.PMID 19420964Read ↗

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