Article
Three classes of genes mutated in colorectal cancers with chromosomal instability.
Cancer research - 1 May 2004
Wang Zhenghe, Cummins Jordan M, Shen Dong, Cahill Daniel P, Jallepalli Prasad V, Wang Tian-Li, Parsons D Williams, Traverso Giovanni, Awad Mark, Silliman Natalie, Ptak Janine, Szabo Steve, Willson James K V, Markowitz Sanford D, Goldberg Michael L, Karess Roger, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E, Lengauer Christoph
Abstract excerpt
Although most colorectal cancers are chromosomally unstable, the basis for this instability has not been defined. To determine whether genes shown to cause chromosomal instability in model systems were mutated in colorectal cancers, we identified their human homologues and determined their sequence in a panel of colorectal cancers. We found 19 somatic mutations in five genes representing three distinct...
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